Tweaking a sample as a Main Loop in several sections of a song

I have a song that I want to use the same sample as the main loop in different parts, with some adjustments, e.g. adding a tambourine, or removing a few tom hits…

If I make those Edits in section 1 of the song, do those changes to that sample then take affect in the other sections of the song using that same loop? I thought you could just make any changes by section and it wouldn’t affect the original sample.

Thanks.

The changes only take place in the song section you edit.