Yes, I tried to put the folder back on the desktop (I should have mentioned this), but I had changed the name of the folder after moving it the first time and I’m not sure of the exact name anymore. I’ve searched but I can’t find in Reaper the path followed by the emulator to find the .drm.
The .drm used (when I run the project in Rosetta mode) is not the one I had used in the initial test project (I had modified it slightly), perhaps Reaper is looking for a path that it can’t find and that causes the application to crash.